Carcinogenicity studies were done with codeine. Two-12 months reports in F344/N rats and B6C3F1 mice were being performed to assess the carcinogenic probable of codeine. No evidence of tumorigenicity was noticed in male and female rats at codeine dietary doses as much as 70 and 80 mg/kg/working day (close to similar to 15 and 20 times, the MRHD on